Publications

  1. H. Syedain, R. Maciver, R. T. Tranquillo, Vascular grafts and valves that animate, made from decellularized biologically-engineered tissue tubes. J Cardiovasc Surg (Torino) 61, 577-585 (2020).
  2. Thrivikraman et al., Biologically-engineered mechanical model of a calcified artery. Acta Biomater 110, 164-174 (2020).
  3. H. Syedain et al., A completely biological “off-the-shelf” arteriovenous graft that recellularizes in baboons. Sci Transl Med 9,  (2017).
  4. Syedain et al., Tissue engineering of acellular vascular grafts capable of somatic growth in young lambs. Nat Commun 7, 12951 (2016).
  5. H. Syedain, L. A. Meier, M. T. Lahti, S. L. Johnson, R. T. Tranquillo, Implantation of completely biological engineered grafts following decellularization into the sheep femoral artery. Tissue Eng Part A 20, 1726-1734 (2014).
  6. A. Meier et al., Blood outgrowth endothelial cells alter remodeling of completely biological engineered grafts implanted into the sheep femoral artery. J Cardiovasc Transl Res 7, 242-249 (2014).
  7. W. Bjork, L. A. Meier, S. L. Johnson, Z. H. Syedain, R. T. Tranquillo, Hypoxic culture and insulin yield improvements to fibrin-based engineered tissue. Tissue Eng Part A 18, 785-795 (2012).
  8. H. Syedain, R. T. Tranquillo, TGF-beta1 diminishes collagen production during long-term cyclic stretching of engineered connective tissue: implication of decreased ERK signaling. J Biomech 44, 848-855 (2011).
  9. H. Syedain, L. A. Meier, J. W. Bjork, A. Lee, R. T. Tranquillo, Implantable arterial grafts from human fibroblasts and fibrin using a multi-graft pulsed flow-stretch bioreactor with noninvasive strength monitoring. Biomaterials 32, 714-722 (2011).
  10. H. Syedain, J. Bjork, L. Sando, R. T. Tranquillo, Controlled compaction with ruthenium-catalyzed photochemical cross-linking of fibrin-based engineered connective tissue. Biomaterials 30, 6695-6701 (2009).
  11. H. Syedain, J. S. Weinberg, R. T. Tranquillo, Cyclic distension of fibrin-based tissue constructs: evidence of adaptation during growth of engineered connective tissue. Proc Natl Acad Sci U S A 105, 6537-6542 (2008).
  12. W. Bjork, S. L. Johnson, R. T. Tranquillo, Ruthenium-catalyzed photo cross-linking of fibrin-based engineered tissue. Biomaterials 32, 2479-2488 (2011).
  13. W. Bjork, R. T. Tranquillo, Transmural flow bioreactor for vascular tissue engineering. Biotechnol Bioeng 104, 1197-1206 (2009).
  14. B. Schmidt, R. T. Tranquillo, Cyclic Stretch and Perfusion Bioreactor for Conditioning Large Diameter Engineered Tissue Tubes. Ann Biomed Eng 44, 1785-1797 (2016).
  15. B. Schmidt, K. Chen, R. T. Tranquillo, Effects of Intermittent and Incremental Cyclic Stretch on ERK Signaling and Collagen Production in Engineered Tissue. Cell Mol Bioeng 9, 55-64 (2016).
  16. La, R. T. Tranquillo, Shear Conditioning of Adipose Stem Cells for Reduced Platelet Binding to Engineered Vascular Grafts. Tissue Eng Part A 24, 1242-1250 (2018).
  1. H. Syedain et al., Pediatric tri-tube valved conduits made from fibroblast-produced extracellular matrix evaluated over 52 weeks in growing lambs. Sci Transl Med 13,  (2021).
  2. H. Syedain, R. Maciver, R. T. Tranquillo, Vascular grafts and valves that animate, made from decellularized biologically-engineered tissue tubes. J Cardiovasc Surg (Torino) 61, 577-585 (2020).
  3. H. Syedain et al., Tissue-engineered transcatheter vein valve. Biomaterials 216, 119229 (2019).
  4. Reimer et al., Implantation of a Tissue-Engineered Tubular Heart Valve in Growing Lambs. Ann Biomed Eng 45, 439-451 (2017).
  5. Syedain et al., 6-month aortic valve implantation of an off-the-shelf tissue-engineered valve in sheep. Biomaterials 73, 175-184 (2015).
  6. M. Reimer, Z. H. Syedain, B. H. Haynie, R. T. Tranquillo, Pediatric tubular pulmonary heart valve from decellularized engineered tissue tubes. Biomaterials 62, 88-94 (2015).
  7. H. Syedain, L. A. Meier, J. M. Reimer, R. T. Tranquillo, Tubular heart valves from decellularized engineered tissue. Ann Biomed Eng 41, 2645-2654 (2013).
  8. H. Syedain, A. R. Bradee, S. Kren, D. A. Taylor, R. T. Tranquillo, Decellularized tissue-engineered heart valve leaflets with recellularization potential. Tissue Eng Part A 19, 759-769 (2013).
  9. W. Bjork, L. A. Meier, S. L. Johnson, Z. H. Syedain, R. T. Tranquillo, Hypoxic culture and insulin yield improvements to fibrin-based engineered tissue. Tissue Eng Part A 18, 785-795 (2012).
  10. H. Syedain, R. T. Tranquillo, TGF-beta1 diminishes collagen production during long-term cyclic stretching of engineered connective tissue: implication of decreased ERK signaling. J Biomech 44, 848-855 (2011).
  11. H. Syedain, R. T. Tranquillo, Controlled cyclic stretch bioreactor for tissue-engineered heart valves. Biomaterials 30, 4078-4084 (2009).
  12. H. Syedain, J. Bjork, L. Sando, R. T. Tranquillo, Controlled compaction with ruthenium-catalyzed photochemical cross-linking of fibrin-based engineered connective tissue. Biomaterials 30, 6695-6701 (2009).
  13. H. Syedain, J. S. Weinberg, R. T. Tranquillo, Cyclic distension of fibrin-based tissue constructs: evidence of adaptation during growth of engineered connective tissue. Proc Natl Acad Sci U S A 105, 6537-6542 (2008).
  14. W. Bjork, S. L. Johnson, R. T. Tranquillo, Ruthenium-catalyzed photo cross-linking of fibrin-based engineered tissue. Biomaterials 32, 2479-2488 (2011).
  15. B. Schmidt, R. T. Tranquillo, Cyclic Stretch and Perfusion Bioreactor for Conditioning Large Diameter Engineered Tissue Tubes. Ann Biomed Eng 44, 1785-1797 (2016).
  16. B. Schmidt, K. Chen, R. T. Tranquillo, Effects of Intermittent and Incremental Cyclic Stretch on ERK Signaling and Collagen Production in Engineered Tissue. Cell Mol Bioeng 9, 55-64 (2016).
  1. A. Schaefer, P. A. Guzman, S. B. Riemenschneider, T. J. Kamp, R. T. Tranquillo, A cardiac patch from aligned microvessel and cardiomyocyte patches. Journal of tissue engineering and regenerative medicine12 (2), 546–556 (2018).
  2. B. Riemenschneider, D. J. Mattia, J. S. Wendel, J. A. Schaefer, L. Ye, P. A. Guzman, R. T. Tranquillo, Inosculation and perfusion of pre-vascularized tissue patches containing aligned human microvessels after myocardial infarction. Biomaterials97, 51–61 (2016).

 

  1. H. Syedain, R. Maciver, R. T. Tranquillo, Vascular grafts and valves that animate, made from decellularized biologically-engineered tissue tubes. J Cardiovasc Surg (Torino) 61, 577-585 (2020).
  2. Thrivikraman et al., Biologically-engineered mechanical model of a calcified artery. Acta Biomater 110, 164-174 (2020).
  3. H. Syedain et al., A completely biological “off-the-shelf” arteriovenous graft that recellularizes in baboons. Sci Transl Med 9,  (2017).
  4. Syedain et al., Tissue engineering of acellular vascular grafts capable of somatic growth in young lambs. Nat Commun 7, 12951 (2016).
  5. H. Syedain, L. A. Meier, M. T. Lahti, S. L. Johnson, R. T. Tranquillo, Implantation of completely biological engineered grafts following decellularization into the sheep femoral artery. Tissue Eng Part A 20, 1726-1734 (2014).
  6. A. Meier et al., Blood outgrowth endothelial cells alter remodeling of completely biological engineered grafts implanted into the sheep femoral artery. J Cardiovasc Transl Res 7, 242-249 (2014).
  7. W. Bjork, L. A. Meier, S. L. Johnson, Z. H. Syedain, R. T. Tranquillo, Hypoxic culture and insulin yield improvements to fibrin-based engineered tissue. Tissue Eng Part A 18, 785-795 (2012).
  8. H. Syedain, R. T. Tranquillo, TGF-beta1 diminishes collagen production during long-term cyclic stretching of engineered connective tissue: implication of decreased ERK signaling. J Biomech 44, 848-855 (2011).
  9. H. Syedain, L. A. Meier, J. W. Bjork, A. Lee, R. T. Tranquillo, Implantable arterial grafts from human fibroblasts and fibrin using a multi-graft pulsed flow-stretch bioreactor with noninvasive strength monitoring. Biomaterials 32, 714-722 (2011).
  10. H. Syedain, J. Bjork, L. Sando, R. T. Tranquillo, Controlled compaction with ruthenium-catalyzed photochemical cross-linking of fibrin-based engineered connective tissue. Biomaterials 30, 6695-6701 (2009).
  11. H. Syedain, J. S. Weinberg, R. T. Tranquillo, Cyclic distension of fibrin-based tissue constructs: evidence of adaptation during growth of engineered connective tissue. Proc Natl Acad Sci U S A 105, 6537-6542 (2008).
  12. W. Bjork, S. L. Johnson, R. T. Tranquillo, Ruthenium-catalyzed photo cross-linking of fibrin-based engineered tissue. Biomaterials 32, 2479-2488 (2011).
  13. W. Bjork, R. T. Tranquillo, Transmural flow bioreactor for vascular tissue engineering. Biotechnol Bioeng 104, 1197-1206 (2009).
  14. B. Schmidt, R. T. Tranquillo, Cyclic Stretch and Perfusion Bioreactor for Conditioning Large Diameter Engineered Tissue Tubes. Ann Biomed Eng 44, 1785-1797 (2016).
  15. B. Schmidt, K. Chen, R. T. Tranquillo, Effects of Intermittent and Incremental Cyclic Stretch on ERK Signaling and Collagen Production in Engineered Tissue. Cell Mol Bioeng 9, 55-64 (2016).
  16. La, R. T. Tranquillo, Shear Conditioning of Adipose Stem Cells for Reduced Platelet Binding to Engineered Vascular Grafts. Tissue Eng Part A 24, 1242-1250 (2018).
  1. H. Syedain et al., Pediatric tri-tube valved conduits made from fibroblast-produced extracellular matrix evaluated over 52 weeks in growing lambs. Sci Transl Med 13,  (2021).
  2. H. Syedain, R. Maciver, R. T. Tranquillo, Vascular grafts and valves that animate, made from decellularized biologically-engineered tissue tubes. J Cardiovasc Surg (Torino) 61, 577-585 (2020).
  3. H. Syedain et al., Tissue-engineered transcatheter vein valve. Biomaterials 216, 119229 (2019).
  4. Reimer et al., Implantation of a Tissue-Engineered Tubular Heart Valve in Growing Lambs. Ann Biomed Eng 45, 439-451 (2017).
  5. Syedain et al., 6-month aortic valve implantation of an off-the-shelf tissue-engineered valve in sheep. Biomaterials 73, 175-184 (2015).
  6. M. Reimer, Z. H. Syedain, B. H. Haynie, R. T. Tranquillo, Pediatric tubular pulmonary heart valve from decellularized engineered tissue tubes. Biomaterials 62, 88-94 (2015).
  7. H. Syedain, L. A. Meier, J. M. Reimer, R. T. Tranquillo, Tubular heart valves from decellularized engineered tissue. Ann Biomed Eng 41, 2645-2654 (2013).
  8. H. Syedain, A. R. Bradee, S. Kren, D. A. Taylor, R. T. Tranquillo, Decellularized tissue-engineered heart valve leaflets with recellularization potential. Tissue Eng Part A 19, 759-769 (2013).
  9. W. Bjork, L. A. Meier, S. L. Johnson, Z. H. Syedain, R. T. Tranquillo, Hypoxic culture and insulin yield improvements to fibrin-based engineered tissue. Tissue Eng Part A 18, 785-795 (2012).
  10. H. Syedain, R. T. Tranquillo, TGF-beta1 diminishes collagen production during long-term cyclic stretching of engineered connective tissue: implication of decreased ERK signaling. J Biomech 44, 848-855 (2011).
  11. H. Syedain, R. T. Tranquillo, Controlled cyclic stretch bioreactor for tissue-engineered heart valves. Biomaterials 30, 4078-4084 (2009).
  12. H. Syedain, J. Bjork, L. Sando, R. T. Tranquillo, Controlled compaction with ruthenium-catalyzed photochemical cross-linking of fibrin-based engineered connective tissue. Biomaterials 30, 6695-6701 (2009).
  13. H. Syedain, J. S. Weinberg, R. T. Tranquillo, Cyclic distension of fibrin-based tissue constructs: evidence of adaptation during growth of engineered connective tissue. Proc Natl Acad Sci U S A 105, 6537-6542 (2008).
  14. W. Bjork, S. L. Johnson, R. T. Tranquillo, Ruthenium-catalyzed photo cross-linking of fibrin-based engineered tissue. Biomaterials 32, 2479-2488 (2011).
  15. B. Schmidt, R. T. Tranquillo, Cyclic Stretch and Perfusion Bioreactor for Conditioning Large Diameter Engineered Tissue Tubes. Ann Biomed Eng 44, 1785-1797 (2016).
  16. B. Schmidt, K. Chen, R. T. Tranquillo, Effects of Intermittent and Incremental Cyclic Stretch on ERK Signaling and Collagen Production in Engineered Tissue. Cell Mol Bioeng 9, 55-64 (2016).
  1. A. Schaefer, P. A. Guzman, S. B. Riemenschneider, T. J. Kamp, R. T. Tranquillo, A cardiac patch from aligned microvessel and cardiomyocyte patches. Journal of tissue engineering and regenerative medicine 12 (2), 546–556 (2018).
  2. B. Riemenschneider, D. J. Mattia, J. S. Wendel, J. A. Schaefer, L. Ye, P. A. Guzman, R. T. Tranquillo, Inosculation and perfusion of pre-vascularized tissue patches containing aligned human microvessels after myocardial infarction. Biomaterials 97, 51–61 (2016).

 

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Vascudyne’s CSO presents at the Heart Valve Society Meeting on tissue remodeling of engineered valved conduit evaluated at 52 weeks in the growing lamb

Lab-created heart valves can grow with the recipient article published in Science Translational Medicine

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